多巴胺联合多巴酚丁胺治疗慢性心力衰竭合并肾功能不全的效果观察

　　[摘要]目的 探讨多巴胺联合多巴酚丁胺治疗慢性心衰合并肾功能不全的效果。方法 选取2014年2月～2016年9月我院收治的60例慢性心衰合并肾功能不全患者作为研究对象，采用随机分配方式将其分为观察组和对照组，每组各30例。对照组患者采用常规药物治疗，观察组患者采用多巴胺联合多巴酚丁胺治疗。比较两组患者的治疗效果、不良反应发生情况以及左室舒张末期内径（LVEDD）、左室射血分数（LVEF）、血尿素氮（BUN）等心肾功能临床指标。结果 观察组患者的治疗总有效率（93.33%）高于对照组（73.33%），差异有统计学意义（P<0.05）。治疗前，两组患者的心肾功能指标比较，差异无统计学意义（P>0.05）。治疗前，两组患者的心肾功能指标比较，差异无统计学意义（P>0.05）。治疗后，两组患者的LVEDD、BUN低于治疗前，LVEF高于治疗前，差异有统计学意义（P<0.05），且观察组患者的LVEDD、BUN显著低于对照组，LVEF指标显著高于对照组，差异均有统计学意义（P<0.05）。观察组患者的不良反应发生率（6.67%）低于对照组（26.67%），差异有统计学意义（P<0.05）。结论 多巴胺联合多巴酚丁胺治疗慢性心衰合并腎功能不全的临床效果显著，能够降低不良反应发生率，有效改善患者的临床症状，值得临床推广。
　　[关键词]多巴胺；多巴酚丁胺；慢性心衰合并肾功能不全；临床效果
　　[中图分类号] R541.61 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0135-03
　　Effect of Dopamine combined with Dobutamine on chronic heart failure with renal insufficiency
　　ZHANG Qing
　　Department of Cardiology，Liaoyang Central Hospital，Liaoning Province，Liaoyang 111000，China
　　[Abstract]Objective To investigate the effect of Dopamine combined with Dobutamine in the treatment of chronic heart failure complicated with renal insufficiency.Methods A total of 60 patients with chronic heart failure complicated with renal insufficiency admitted in our hospital from February 2014 to September 2016 were selected as subjects，and they were divided into observation group and control group by random distribution，30 cases in each group.The control group was treated with conventional drugs.The observation group was treated with Dopamine and Dobutamine.The effects of treatment，adverse reactions and the left ventricular diastolic （LVEDD），left ventricular ejection fraction （LVEF） and blood urea nitrogen （BUN） of the two groups were compared.Results The total effective rate in the observation group （93.33%） was higher than that in the control group （73.33%），and the difference was statistically significant （P<0.05）.Before treatment，there was no statistically significant difference between the two groups of patients with heart and kidney function （P>0.05）.After treatment，the LVEDD and BUN were lower than before treatment in both groups，the LVEF was higher than before the treatment，and the differences were statistically significant （P<0.05）.The LVEDD and BUN of patients in the observation group were significantly lower than those in the control group，while the LVEF was significantly higher than that in the control group，and the differences were statistically significant （P<0.05）.The incidence of adverse reactions in the observation group （6.67%） was lower than that in the control group （26.67%），and the difference was statistically significant （P<0.05）.Conclusion The clinical effect of Dopamine combined with Dobutamine in the treatment of chronic heart failure complicated with renal insufficiency is significant，which can reduce the incidence of adverse reactions and effectively improve the clinical symptoms of patients，it is worthy of clinical promotion.

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