乳腺癌根治术后不同放疗技术的应用与剂量分析

　　摘 要 目的：分析乳腺癌根治术后不同放疗技术的应用与剂量。方法：选取2012年2月至2016年4年收治的乳腺癌根治术后患者30例，随机分为对照组与观察组各15例。对照组采用普通放疗计划，观察组采用三维适形放疗，均根据处方剂量50 Gy进行放疗。观察比较两组计划靶区（PTV）剂量参数、分次治疗时间以及近期不良反应。结果：观察组PTV各剂量参数显著低于对照组（P<0.05），分次治疗时间明显短于对照组（P<0.05），近期不良反应发生率为6.67%（1/15），低于对照组的20.0%（3/15，P<0.05）。结论：乳腺癌根治术后采用三维适形放疗的效果更为显著，即靶区剂量覆盖均匀性显著较高，且能显著减少危急器官的平均剂量以及高剂量区体积，同时还能减少各种近期不良反应，值得推广应用。
　　关键词 乳腺癌；放射治疗；剂量
　　中图分类号：R737.9 文献标志码：A 文章编号：1006-1533（2018）04-0019-02
　　Application and dose analysis of different radiotherapy techniques after radical mastectomy for the breast cancer
　　ZHU Tong
　　（Oncology Department of Central People’s Hospital of Jian， Jian 343000， Jiangxi Province， China）
　　ABSTRACT Objective： To analyze the application and dosage of different radiotherapy techniques after radical mastectomy. Methods： Thirty cases of breast cancer after radical mastectomy in 4 years from February 2012 to February 2016 were selected and randomly divided into a control group and an observation group with 15 cases each. The control group was treated with a general radiotherapy plan， and three-dimensional conformal radiotherapy was used in the observation group and the radiotherapy was performed on the basis of prescription agent 50 Gy. The dose parameters， fractional treatment time and shortterm adverse reactions of planned target area （PTV） in two groups were observed and compared. Results： The dose of PTV in the observation group was significantly lower than that in the control group（P<0.05）. The treatment time of the observation group was significantly shorter than that of the control group（P<0.05）. The incidence of recent adverse reactions was 6.67%（1/15）， which was lower than that of the control group 20%（3/15）（P<0.05）. Conclusion： The effect of Three-dimensional conformal radiotherapy is more significant after radical mastectomy. That is the dose coverage uniformity in the target area is significantly higher， and it can significantly reduce the average dose of critical organs and the volume of high dose area. At the same time， it can also reduce a variety of adverse reactions in the near future， which is worth popularizing.
　　KEY WORDS breast cancer； radiotherapy； dose
　　目前，针对乳腺浸润性导管癌，临床综合治疗手段主要为放射治疗，能有效减少患者的术后复发率和死亡率[1-2]。但在乳腺癌根治术后，患者容易出现各种不良反应[3]。本文对乳腺癌根治术后不同放疗技术的应用与剂量进行了研究与分析，现报道如下。
　　1 资料与方法
　　1.1 一般资料
　　选取2012年2月至2016年4年吉安市中心人民医院肿瘤科收治的乳腺癌根治术后患者30例，采用计算机随机分为对照组和观察组各15例。对照组年龄25～60岁，平均（45.2±3.6）岁，观察组年龄26～63歲，平均（46.3±2.7）岁。两组基本资料差异无统计学意义（P>0.05）。

相关热词搜索：放疗 乳腺癌 剂量 术后 根治