高血压病合并糖调节受损患者血压变异性的相关研究

　　摘要：目的  探討高血压病合并糖调节受损（IGR）患者血糖水平与血压变异性的关系。方法  选取2016年5月～2017年5月在承德医学院附属医院全科医疗科住院的高血压病患者，依据口服葡萄糖耐量试验（OGTT），分为IFG组（A组）41例，IGT组（B组）42例，IFG+IGT组（C组）40例，并以46例糖耐量正常（NGT）的高血压患者作为对照组（D组）。所有患者均进行24 h动态血压监测，观察各组患者24hSBP、24hDBP、24hAPP、24hmSBPCV、24hmDBPCV等血压变异性指标的特点。结果  各组间性别、年龄、体重、高血压病程、家族史，以及FPG、2hPBG、HbAlc、TG比较，差异无统计学意义（P>0.05）。A、B、C三组24hSBP、24hDBP、24hAPP与D组相比，差异无统计学意义（P>0.05）;A、B、C三组24hmSBPCV、24hmDBPCV均高于D组，差异有统计学意义（P<0.05），以24hmSBPCV最为显著（P<0.01），但IFG组、IGT组两组间比较，差异无统计学意义（P>0.05）。结论  高血压病合并IGR是导致血压变异性增加的重要因素，对高血压患者靶器官损害产生重要作用。
　　关键词：糖调节受损;原发性高血压;血压变异性
　　中图分类号：R544.1                              文献标识码：A                                    DOI：10.3969/j.issn.1006-1959.2018.05.004
　　文章编号：1006-1959（2018）05-0011-03
　　Study on Blood Pressure Variability in Patients with Hypertension Complicated with Impaired Glucose Regulation
　　DUAN Shu-ting1，WANG Yi-wei2，WANG Zhao-peng2
　　（1.Chengde Medical College，Chengde 067000，Hebei，China;
　　2.Hospital Affiliated to Chengde Medical College，Chengde 067000，Hebei，China）
　　Abstract：Objective  To investigate the relationship between blood glucose level and blood pressure variability in patients with hypertension complicated with impaired glucose regulation.Methods  From May 2016-May 2017 hypertension patients in affiliated hospital of Chengde Medical College，according to oral glucose tolerance test （OGTT），divided into IFG group（A group）41 cases，IGT group（B group）42 cases，IFG+IGT group（C group）40 cases，46 hypertensive patients with normal glucose tolerance（NGT）were used as control group（group D）.24 h ambulatory blood pressure monitoring was performed in all patients，and the characteristics of blood pressure variability indexes such as 24hSBP，24hDBP，24hAPP，24hmSBPCV and 24hmDBPCV were observed in all the patients. Results  There was no significant difference in sex，age，body weight，course of hypertension，family history and FPG，2hPBG，HbAlc，TG between the two groups（P>0.05）.Compared with D group，there was no significant difference in 24 h SBP，24 h DBP and 24 h APP between the A，B C three groups（P>0.05）.As for 24hmSBPCV，24hmDBPCV，A，B，C three groups were higher than the D group，the difference was statistically significant（P<0.05），and 24hmSBPCV was the most significant（P<0.01）.But there was no significant difference between the IFG group and IGT groups（P>0.05）.Conclusion  Hypertension combined with IGR is an important factor to increase blood pressure variability and plays an important role in target organ damage in patients with hypertension.

相关热词搜索：变异性 高血压 受损 合并 血压