醋酸甲地孕酮治疗子宫内膜癌的临床效果

　　[摘要]目的 探讨醋酸甲地孕酮治疗子宫内膜癌的临床效果。方法 选择2016年7月～2017年7月我院收治的80例子宮内膜癌患者，遵循患者的个人意愿进行分组治疗。其中，39例患者选择常规治疗，设为对照组，另外41例子宫内膜癌患者设为观察组，选择在对照组的基础上应用醋酸甲地孕酮强化治疗。对比两组患者的治疗效果以及生活质量改善情况。结果 经过治疗后，两组子宫内膜癌患者均出现不同程度的胃肠道反应，观察组患者的胃肠道反应发生率为9.76%，显著低于对照组的35.90%，差异有统计学意义（P<0.05）。观察组患者的复发率为7.32%，对照组为30.77%，两组比较，差异有统计学意义（P<0.05）。观察组患者治疗后的生活质量各项评分均高于对照组（P<0.05）。结论 醋酸甲地孕酮在治疗子宫内膜癌患者中的临床价值确切，不仅能够减少患者的胃肠道反应、复发率，还可以显著提高子宫内膜癌患者的生活质量，在临床上的应用效果非常重要，值得进一步探讨研究。
　　[关键词]醋酸甲地孕酮；子宫内膜癌；临床效果
　　[中图分类号] R737.3 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0083-03
　　Clinical effect of Megestrol Acetate in the treatment of endometrial carcinoma
　　WANG Jing
　　Department of Gynecology，AnshanTumor Hospital in Liaoning Province，Anshan 114000，China
　　[Abstract]Objective To investigate the clinical effect of Megestrol Acetate in the treatment of endometrial carcinoma.Methods From July 2016 to July 2017，80 patients with endometrial cancer in our hospital were treated.According to their personal will，they were grouped.Among them，39 patients were treated with routine therapy，and the rest 41 patients with endometrial carcinoma treated with Megestrol Acetate on the basis of the control group for intensification.Patients treated by routine therapy was classified into control group，and by intensified treatment was categorized into observation group.The therapeutic effect and improvement of quality of life between the two groups were compared.Results After treatment，patients with endometrial cancer in the two groups occurred with gastrointestinal reactions to some extent.The incidence of gastrointestinal reaction in the observation group was 9.76%，significantly lower than that in the control group accounting for 35.90% with a statistical difference（P<0.05）.The recurrence rate was 7.32% in the observation group and 30.77% in the control group，which was displayed statistical significance after comparison （P<0.05）.The scores of quality of life in the observation group were all higher than those in the control group （P<0.05）.Conclusion Application of Megestrol Acetatein the treatment of endometrial cancer obtains a definite clinical value.It not only reduces the patient′s gastrointestinal reaction and recurrence rate，but also markedly improve the quality of life in endometrial cancer patients，which plays a vital role in clinical practice and is worthy of further study and exploration.
　　[Key words]Megestrol Acetate；Endometrial carcinoma；Clinical effect
　　子宫内膜癌是妇科较为常见的疾病，近年来发病率呈现上升趋势，该疾病的发生率在妇科常见病中仅次于宫颈癌和乳腺癌，已经严重危害到女性患者的身体健康和生活质量[1]。大部分子宫内膜癌患者经确诊后首先进行手术治疗，但是由于子宫内膜癌晚期患者复发率较高，预后效果较差，因此需要给予放疗、化疗、激素治疗作为辅助方法，以降低癌细胞的转移和复发，对控制患者的病情，提高其生活质量起到重要作用[2]。笔者以醋酸甲地孕酮进行辅助治疗，探究该治疗方法对提高子宫内膜癌患者的生活质量的意义，旨在为以后的临床研究提供参考依据，现报道如下。

相关热词搜索：醋酸 子宫内膜 临床 效果 治疗