中西医结合治疗小儿慢性腹泻的效果观察

　　【摘要】 目的：觀察中西医结合治疗小儿慢性腹泻的效果及对血清相关炎症细胞因子变化表达的影响。方法：选取笔者所在医院收治的200例慢性腹泻患儿为研究对象，随机将其分成试验组和对照组各100例。对照组采用常规的临床治疗方法，试验组采用中西医结合治疗，对两组患儿治疗效果及血清相关炎症细胞因子变化[结肠黏膜核因子-κB（NF-κB）、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）和白介素-8（IL-8）]进行对比。结果：治疗后，试验组及对照组临床治疗总有效率分别为96.0%和80.0%，试验组临床治疗总有效率明显优于对照组，差异有统计学意义（P<0.05）；试验组不良反应发生率4.0%（4例），明显低于对照组的12.0%（12例），两组差异有统计学意义（P<0.05）。试验组血清NF-κB、TNF-α、IL-6和IL-8分别为（43.8±11.5）ng/L、（67.9±11.5）pg/ml、（122.2±25.6）pg/ml和（24.6±6.5）ng/ml；对照组血清NF-κB、TNF-α、IL-6和IL-8分别为（85.4±12.6）ng/L、（93.7±14.6）pg/ml、（183.2±31.6）pg/ml和（32.3±7.4）ng/ml；试验组临床治疗血清相关炎症细胞因子明显低于对照组，差异均有统计学意义（P<0.05）。结论：中西医结合治疗小儿慢性腹泻对小儿肠黏膜具有修复和抗炎作用，抑制NF-κB的激活，下调TNF-α、IL-6和IL-8，效果显著，值得临床上推广应用。
　　【关键词】 小儿慢性腹泻； 细胞因子； 中西医
　　doi：10.14033/j.cnki.cfmr.2018.5.003 文献标识码 A 文章编号 1674-6805（2018）05-0005-03
　　【Abstract】 Objective：To observe the effect of traditional Chinese medicine and western medicine in the treatment of chronic diarrhea in children and the expression of serum related inflammatory cytokines.Method：We selected 200 children with chronic diarrhea in our hospital as the research object，who were randomly divided into the experimental group and the control group of 100 cases.The control group used conventional clinical treatment.The experimental group was treated with traditional Chinese medicine and western medicine.The therapeutic effects of the two groups were compared.The changes of serum-associated inflammatorycytokines[Colonic mucosal nuclear factor-κB（NF-κB），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6） and interleukin-8 （IL-8）] in the two groups were compared.Result：After treatment，The total effective rate of clinical treatment in the experimental group and the control group were 96.0% and 80.0% respectively.The total effective rate of clinical treatment in the experimental group was significantly better than that in the control group（P<0.05）.The adverse reaction rate was 4.0%（4 cases） in the experimental group and 12.0%（12 cases） in the control group，the difference was statistically significant（P<0.05）.The levels of serum NF-κB，TNF-α，IL-6 and IL-8 in the experimental group were （43.8±11.5）ng/L，（67.9±11.5）pg/ml，（122.2±25.6）pg/ml and （24.6±6.5）ng/ml.The levels of serum NF-κB， TNF-α，IL-6 and IL-8 in the control group were （85.4±12.6）ng/L，（93.7±14.6）pg/ml，（183.2±31.6）pg/ml and （32.3±7.4）ng/ml.The serum levels of serum-related inflammatory cytokines in the experimental group were significantly lower than those in the control group（P<0.05）.Conclusion：The combination of traditional Chinese and western medicine in the treatment of chronic diarrhea in children with intestinal inflammation and anti-inflammatory are effect，inhibit NF-κB activation，down-regulation of TNF-α，IL-6 and IL-8，the effect is significant，worthy of clinical application.

相关热词搜索：腹泻 小儿 中西医结合 观察 效果