肺癌放射治疗致放射性肺炎的临床效果

　　[摘要]目的 探讨肺癌放射治疗致放射性肺炎的临床效果。方法 选择2013年1月～2016年12月在我院行放射治疗所致放射性肺炎的74例肺癌患者，依据不同治疗方案分为对照组、观察组，每组37例。对照组实施常规西医治疗，观察组实施中西医结合治疗，比较两组患者的临床疗效、症状改善情况、炎症因子水平、KPS评分及不良反应。结果 观察组的总有效率显著高于对照组，差异有统计学意义（P<0.05）；观察组患者治疗后症状评分显著低于对照组，差异有统计学意义（P<0.05）；观察组治疗后白细胞计数、hs-CRP显著低于对照组，差异有统计学意义（P<0.05）；观察组治疗后KPS评分显著高于对照组；差异有统计学意义（P<0.05）；观察组的不良反应发生率显著低于对照组，差异有统计学意义（P<0.05）。结论 肺癌放射治疗致放射性肺炎采用中西医结合治疗有良好效果，能有效缓解症状，促进炎症的消退，提高患者生存质量，具有积极的临床意义。
　　[关键词]肺癌放射治疗；放射性肺炎；中西医结合治疗
　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0077-03
　　Clinical effect of radiotherapy on radiation pneumonitis caused by lung cancer
　　CHEN Hai-wen ZHANG Kun-qiang YANG Chang-fu LU Yao-yong WEI Hua-jun
　　Department of Oncology， People′s Hospital in Gaozhou City of Guangdong Province，Gaozhou 525200，China
　　[Abstract]Objective To investigate the clinical effect of radiation pneumonitis induced by lung cancer radiotherapy.Methods 74 lung cancer patients with radiation pneumonitis caused by radiotherapy in our hospital from January 2013 to December 2016 were selected and divided into control group and observation group according to different treatment schemes，with 37 cases in each group.The control group was treated with conventional western medicine，and the observation group was treated with integrated traditional Chinese and Western medicine.The clinical efficacy，symptom improvement，inflammatory factor level，KPS score and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group （P<0.05）.After treatment，the symptom score of the observation group was significantly lower than that of the control group （P<0.05）.After treatment，the white blood cell count and hs-CRP in the observation group were significantly lower than those in the control group （P<0.05）.KPS score of observation group was significantly higher than that of control group，the difference was statistically significant （P<0.05）.The incidence of adverse reactions in the observation group was significantly lower than that in the control group （P<0.05）.Conclusion Radiation pneumonitis caused by lung cancer radiotherapy has good effect，can effectively relieve symptoms，promote the regression of inflammation，improve the quality of life of patients， has a positive clinical significance.
　　[Key words]Lung cancer radiotherapy；Radiation pneumonitis；Integrated traditional Chinese and Western medicine treatment
　　肺癌是臨床常见的肿瘤类型，对不能手术治疗、不愿意行手术治疗或因年纪大且基础病多而难以接受手术的肺癌患者，放疗是其主要的治疗手段，临床研究显示患者采用放疗能提高患者的肿瘤局部控制率和生存率。但是放射性肺炎（radiation pneumonitis，RP）是其最常见的并发症，临床发病率达9%～28%[1]，可引发肺纤维化、肺功能不全等慢性并发症，导致治疗失败，甚至危及生命。因此，积极防治RP对放疗效果的发挥和生活质量的提高有重要的临床意义。西医治疗本病多采用糖皮质激素联合抗生素治疗的方式，有较好疗效，但长期使用存在显著不良反应[2]。中医辨证论治具有良好的扶正固本、祛邪外出的功效。本研究分析中西医结合治疗肺癌放射治疗所致RP，评估对患者治疗和预后的影响，现报道如下。

相关热词搜索：肺癌 放射 临床 效果 性肺炎