活化蛋白C在重症肺炎患者预后评估中的应用价值

　　[摘要]目的 觀察重症肺炎患者血清中活化蛋白C（APC）的表达水平，评判其在评估重症肺炎患者预后评估中的价值。方法 选择2013年10月～2016年7月我科诊治重症肺炎患者54例，按预后分为存活组（30例）和死亡组（24例）。随机选取同期我院的非重症肺炎患者30例作为非重症肺炎组，选取同期在我院查体的健康人30例作为健康组，采用酶联免疫吸附法检测各组血清中的APC水平。结果 肺炎组患者与健康人比较，肺炎组的APC水平为（330.81±72.80）ng/ml，低于健康组[（436.57±62.69）ng/ml]，差异有统计学意义（P<0.05）；重症肺炎组的APC水平为（296.60±58.26）ng/ml，低于非重症肺炎组[（392.38±53.52）ng/ml]，差异有统计学意义（P<0.05）；死亡组的APC水平为（263.89±53.53）ng/ml，低于存活组[（322.75±48.34）ng/ml]，差异有统计学意义（P<0.05）。结论 血清中APC水平与肺炎相关，APC水平反应患者疾病严重程度，且与重症肺炎预后相关，APC水平越低，患者预后越差。
　　[关键词]重症肺炎；活化蛋白C；全身性炎症反应综合征；急性肺损伤/急性呼吸窘迫综合征；多器官功能不全
　　[中图分类号] R563.1 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0038-03
　　The application value of APC level for the prognosis assessment of patients with severe pneumonia
　　MU Wei-feng DONG Mao-xuan
　　ICU，Fangzi District People′s Hospital of Weifang City，Shandong Province，Weifang 261206，China
　　[Abstract]Objective To observe the level of serum activated protein C（APC） in patients with severe pneumonia and evaluate its value in evaluating the prognosis of patients with severe pneumonia.Methods A total of 54 patients with severe pneumonia were selected from October 2013 to July 2016，the prognosis was divided into survival group （n=30） and death group （n=24）.30 patients with non-severe pneumonia were selected randomly in the same period，as a non-severe pneumonia group.A healthy group of 30 healthy people were selected in our hospital during the same period.Using enzyme-linked immunosorbent method to detect each group APC level in the serum.Results The APC level of the pneumonia group was （330.81±72.80） ng/ml，which was lower than that the healthy group [（436.57±62.69） ng/ml]，and the difference was statistically significant（P<0.05）.The APC level of the severe pneumonia group was （296.60±58.26） ng/ml，which was lower than that the non-severe pneumonia group [（392.38±552） ng/ml]，and the difference was statistically significant （P<0.05）.The APC level of the death group was （263.89±53.53） ng/ml，which was lower than that the survival group [（322.75±48.34） ng/ml]， and the difference was statistically significant （P<0.05）.Conclusion Level of APC in serum is associated with pneumonia，and the level of APC reflects the severity of the disease and is related to the prognosis of severe pneumonia.The lower the APC level，the worse the prognosis of the patients.
　　[Key words]Severe pneumonia；Activated protein C；System inflammatory response syndrome；Acute lung injury/Acute respiratory distress syndrome；Multiple organ dysfunction syndrome

相关热词搜索：预后 活化 肺炎 重症 蛋白