自拟降压方治疗顽固性高血压的临床疗效及对Hcy、AngⅡ的影响

　　摘要：目的 探讨自拟降压方治疗顽固性高血压的临床疗效。方法 将64例顽固性高血压患者为研究对象，按随机数字表法分为观察组33例和对照组31例，对照组采用西医规范治疗，观察组在此基础上给予口服自拟降压方联合降压方足浴治疗，疗程3月。结果 2组患者的收缩压及舒张压均出现了下降，差異有统计学意义（P<0.05），但下降程度及血压达标率，观察组明显优于对照组，差异有统计学意义（P<0.05）。2组患者的AngⅡ平均较前下降，差异有统计学意义（P<0.05），但改善程度观察组优于对照组，差异有统计学意义（P<0.05）；2组患者的Hcy平均较前下降，观察组治疗前后比较，差异有统计学意义（P<0.05）；对照组治疗前后比较，差异无统计学意义（P>0.05）。2组患者的SAS、SDS、SPIEGEL评分均出现改善，差异有统计学意义（P<0.05），但改善程度，观察组明显优于对照组，差异有统计学意义（P<0.05）。结论 自拟降压方能改善焦虑、抑郁情绪，降低Hcy、AngⅡ的水平，达到控制高血压，提高临床疗效。
　　关键词：疏肝熄风；顽固性高血压；焦虑；抑郁
　　中图分类号：R544.1 文献标志码：B 文章编号：1007-2349（2018）02-0033-03
　　Clinical Curative Effect 0f Self-made Antihypertensive Prescription on Treatment
　　of Refractory Hypertension and its Effect on Hcy and AngⅡ
　　HE Zhi-liang， GAO Jiang-bao， SUN Wu， CHEN Guan-zi
　　（Panyu District Hospital of Traditional Chinese Medicine， Guangzhou， 511400， China）
　　【Abstract】Objective： To study the clinical effect of self-made antihypertensive prescription on the treatment of refractory hypertension. Methods： 64 patients were divided into an observation group （n=33） and a control group （n=31） according to random number table. The control group was given western medicine of standard treatment. The observation group， on the basis of western medicine of the control group， was given oral self-made antihypertensive decoction combined with foot bath treatment. The course was 3 months. Results： The systolic and diastolic blood pressures of the two groups decreased and the difference was significant （P<0.05）， but the degree of decline and blood pressure compliance rate of the observation group were significantly higher than those of the control group （P<0.05）. The mean AngⅡof the patients in the two groups was lower than before and the difference was statistically significant（P<0.05）， but the degree of improvement in the observation group was superior to that in the control group， with a significant difference （P<0.05）. The mean Hcy of the two groups decreased than before. The comparison of pre-and-post treatment of the observation group showed the difference was statistically significant （P<0.05）， The comparison of pre-and-post treatment of the control group showed the difference was not statistically significant （P>0.05）. The scores of SAS， SDS and SPIEGEL in the two groups improved， and the difference was statistically significant （P<0.05）， but the improvement in the observation group was better than that in the control group and the difference was statistically significant （P<0.05）. Conclusion： Self-made hypotension prescription can improve anxiety and depression， reduce the levels of Hcy and AngⅡand achieve the goal of controlling hypertension and improving clinical effectiveness.

相关热词搜索：顽固性 降压 高血压 疗效 临床