注射用生长抑素治疗肝硬化食管胃底静脉曲张破裂出血的效果探讨

　　[摘要] 目的 探讨注射用生长抑素治疗肝硬化食管胃底静脉曲张破裂出血的效果。方法 采用随机数字法将方便选取的2016年1月—2017年2月该院消化科室78例肝硬化食管胃底静脉曲张破裂出血患者分为参照组和研究组进行统计分析，每组实验样本确定为39例，参照组采用埃索美拉唑治疗，研究组采用生长抑素治疗，评估两组患者的治疗效果、治疗前及治疗后24、72 h呕血次数、呕血量、黑便次数、黑便量、平均止血时间、平均输血量以及不良反应发生率。结果 研究组患者的治疗总有效率（94.87%）高于参照组（76.92%）；治疗后24、72 h研究组患者的呕血次数、呕血量、黑便次数以及黑便量少于参照组；平均止血时间短于参照组，平均输血量少于参照组；不良反应发生率（2.50%）低于参照组（17.90%）（P<0.05）。结论 采用生长抑素治疗肝硬化食管胃底静脉曲张破裂出血患者，患者的治疗效果显著，治疗后24、72 h呕血次数、呕血量、黑便次数以及黑便量较少，平均止血时间较短，平均输血量少，不良反应发生率低，要用安全性较高，值得临床学习。
　　[关键词] 生长抑素；肝硬化食管胃底静脉曲张破裂出血；临床效果
　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）01（c）-0135-04
　　[Abstract] Objective This paper tries to investigate the effect of somatostatin injection in the treatment of esophageal variceal rupture of cirrhosis. Methods A total of 78 patients with cirrhotic esophageal and gastric variceal rupture from January 2016 to February 2017 in digestive department were convenient selected and by random number method， they were divided into two groups： the control group and the study group. The experimental samples were identified as 39 cases in each group， The control group was treated with esomeprazole and the study group was treated with somatostati， the therapeutic effect of the two groups was evaluated. The number of hematemesis， the number of vomiting blood， the number of melena， the amount of black chop， the time of hemostasis， mean blood transfusion and the incidence of adverse reactions after 24 and 72 hours of treatment. Results The total effective rate（94.87%） was higher in the study group than in the control group （76.92%）. The number of hematemesis， hematemesis， melatonin and black volume were lower in the study group at 24 and 72 hours after treatment. The average hemostasis time was shorter than the control group， the average blood transfusion less than the control group. The incidence of adverse reactions was 2.50% lower than that of the reference group of 17.90%（P<0.05）. Conclusion The effect of somatostatin on the treatment of cirrhosis， esophageal and gastric variceal bleeding is significant. The number of hematemesis， hematemesis， the number of melena and the amount of melena are lower at 24 and 72 hours after treatment， and the average hemostasis is shorter， the average blood transfusion is less， the incidence of adverse reactions is fewer， with higher safety of medicine， which is worthy of clinical study.
　　[Key words] Somatostatin； Cirrhosis esophageal variceal bleeding； Clinical effect
　　食管靜脉曲张破裂出血是肝硬化较为常见的并发症，该病的发病率较高，有关研究表明，该病的发病率大约在5%～15%之间，再次出血率及病死率分别达到50%和30%以上，严重影响患者的生命健康和生活质量。因此，临床上需要采用积极有效的治疗方法控制并预防患者出现再出血[1]。目前，临床上采用的药物治疗在食管静脉曲张破裂出血方面得到较好的应用，一方面可使得患者获得了良好的止血效果，另一方面不对患者的血流动力学改变造成较大的影响，无严重的不良反应，药用安全性高。该次研究就2016年1月—2017年2月该院消化科室收治的78例肝硬化食管胃底静脉曲张破裂出血患者进行分析，报道如下。

相关热词搜索：食管 肝硬化 静脉曲张 破裂 出血