高危型人乳头瘤病毒分型检测对宫颈癌及癌前病变筛查的意义

　　[摘要] 目的 分析高危型人乳头瘤病毒分型检测对宫颈癌及癌前病变筛查的意义。 方法 本文观察对象为本院2016年7～12月期间收治的50例患者，所有患者均接受高危型人乳头瘤病毒分型检测，对检测情况、检测对宫颈癌和癌前病变筛查的意义进行比较分析。 结果 高危型人乳头瘤病毒感染率为60.00%（30/50），经宫颈活检病理学检查之后，子宫颈上皮非典型增生Ⅰ率为33.33%，子宫颈上皮非典型增生Ⅱ率为10.00%，子宫颈上皮非典型增生Ⅲ率为26.67%，宫颈癌率为30.00%，发现不同宫颈病变的高危型人乳头瘤病毒感染率亦有差异。 结论 高危型人乳头瘤病毒分型检测在宫颈癌与癌前病变筛查当中有重要意义与指导作用存在。
　　[关键词] 宫颈癌；癌前病变；高危型人乳头瘤病毒；分型检测
　　[中图分类号] R737.33 [文献标识码] B [文章编号] 1673-9701（2018）08-0119-03
　　Significance of typing detection of high risk human papillomavirus in screening cervical cancer and precancerous lesions.
　　WU Jieru
　　Department of Laboratory，Jiangxi Provincial Maternal and Child Health Hospital，Nanchang 330006，China
　　[Abstract] Objective To analyze the significance of high-risk human papillomavirus（HPV） typing detection in screening cervical cancer and precancerous lesions. Methods 50 patients admitted in our hospital between July to December 2016 were observed in this study. All patients underwent high-risk human papillomavirus genotyping detection. The detection situation and the significance of detection in screening cervical cancer and precancerous lesions were compared and analyzed. Results The probability of high-risk human papillomavirus infection was 60.00%（30/50）. After cervical biopsy pathology， the probability of atypical hyperplasiaⅠof cervical epithelium was 33.33% and the probability of atypical hyperplasia Ⅱ of cervical epithelium was 10.00%. The probability of cervical epithelial atypical hyperplasia Ⅲ was 26.67%， the probability of cervical cancer was 30.00%. It was found that there was difference in high-risk human papillomavirus infection probability between different cervical lesions. Conclusion High-risk human papillomavirus（HPV）typing detection plays an important role in screening cervical cancer and precancerous lesions.
　　[Key words] Cervical cancer；Precancerous lesions；High-risk human papillomavirus；Typing detection 女性出现宫颈癌与癌前病变主要诱因即为宫颈长时间处于持续性感染高危型人乳头瘤病毒状态中[1]。高危型人乳头瘤病毒分型主要包含高危型與低危型两种，而开展高危型人乳头瘤病毒分型检测可以对疾病演变情况进行诊断，同时可以对疾病的预后进行有效的评估[2]。本文为分析高危型人乳头瘤病毒分型检测应用于宫颈癌及癌前病变筛查当中的价值，特抽选部分患者进行对比与分析，现报道如下。
　　1 资料与方法
　　1.1 一般资料
　　选择2016年7～12月在本院妇产科接受治疗的50例患者进行研究，年龄21～60岁，平均（45.56±2.08）岁；怀孕次数为0～5次，平均（2.19±0.37）次；产次0～3次，平均（2.09±0.08）次。
　　入选标准：有经历性生活者；未曾接受过子宫相关手术治疗者；未患宫颈癌及癌前病变者；有不同程度白带异常（出血与增多）、宫颈充血症状存在者；有完整临床病历资料者；对本次研究知情并且自愿加入者；纳入研究前3个月内未服用性激素类药物治疗者；纳入研究前1周内未接受阴道冲洗、阴道注入药物及药物涂抹阴道等治疗者。
　　排除标准：未曾经历过性生活者；曾接受过子宫相关手术治疗者；经临床相关诊断及检查措施被确诊为癌前病变或者宫颈癌者；同期有加入其他研究项目者；无意愿纳入至本次研究者。

相关热词搜索：宫颈癌 病变 筛查 意义 检测