基于中医传承辅助平台软件分析治疗失眠膏方的组方规律

　　中图分类号 R256.23 文献标志码 A 文章编号 1001-0408（2018）23-3236-05
　　DOI 10.6039/j.issn.1001-0408.2018.23.15
　　摘 要 目的：分析治疗失眠膏方的组方规律，为中医治疗失眠提供参考。方法：整理《中医方剂大辞典》《中医膏丹丸散大典·膏劑分典》《中华膏滋方系列丛书》等记载的治疗失眠的膏方，并录入中医传承辅助平台软件V2.5中统计药材用药频次；运用Apriori算法及关联规则对膏方核心组合进行统计分析（支持度为20%，置信度为0.80）；采用熵聚类算法统计2味不同药材间的关联系数（相关系数为8，惩罚系数为2）和3、4味药材核心组合，根据无监督的熵层次聚类法提取新方。结果：共筛选出125首治疗失眠的膏方，包含236种药材，其中用药频次≥20次的有28味，安神药7味、养血补肝药5味、健脾祛湿药3味、补气药5味、补血药4味、活血药2味、清热药2味；得到常用药材组合28个，其中频次排前3的药材组合分别为酸枣仁-远志、茯苓-酸枣仁、茯苓-远志，茯苓、酸枣仁、远志分别具有健脾化湿、养心安神、宁心定志的功效；得到关联规则12个，3味药材核心组合56个，4味药材核心组合16个；提取治疗失眠的新方7首。结论：失眠膏方单味药功效以安神、养血补肝、补气活血为主。膏方药材组合功效以健脾、养心、定志为主。新方组方特点呈现多样性，以疏肝泻火、解郁安神、消导和中为主，可为临床治疗失眠提供参考。
　　关键词 膏方；失眠；Apriori算法；组方规律；中医传承辅助平台
　　ABSTRACT OBJECTIVE： To analyze the composition rules of paste formulas for insomnia and to provide reference for TCM in the treatment of insomnia. METHODS： The paste formulas for insomnia were collected from TCM Prescription Dictionary， TCM Plaster Pill Powder Dictionary·Ointment Sub-dictionary and Zhonghua Gao Zi Formula Series. The paste formulas were imported into the software of TCM inheritance support platform V2.5 to count the frequency of drug use. Apriori algorithm and association rules were used to analyze core combination of paste formulas statistically （support degree of 20%， confidence degree of 0.80）. Entropy clustering algorithm was used to calculate the correlation coefficients 2 ingredients of different medicines （correlation coefficient of 8， penalty coefficient of 2） and the core combination of medecine 3 and 4 ingredients. The new formula was extracted by unsupervised entropy hierarchical clustering method. RESULTS： Totally 125 paste formulas including 236 medicinal herbs were screened； the use frequency of 28 ingredients was greater or equal to 20 times， there were 7 ingredients for sedation， 5 ingredients for nourishing the blood and nourishing the liver， 3 ingredients for invigorating the spleen and dispelling dampness， 5 ingredients for eich the qi， 4 ingredients for invigorate the supplement of blood， 2 ingredients for invigorate the circulation of blood， 2 ingredients for clearing heat. There were 28 common couplet medicines； top 3 couplet medicines in the list of frequency were Z. jujube-P. tenuifolia， P. cocos-Z. jujube， P. cocos-P. tenuifolia. P. cocos， Z. jujube and P. tenuifolia had the functions of invigorating the spleen and dampness， nourishing the mind， tranquilizing the mind and settling mind. 12 correlation regularities， 56 core combinations of 3 ingredients and 16 core combinations of 4 ingredients were obtained，and 7 new formulas for insomnia were obtained. CONCLUSIONS： The effect of the single ingredients of paste formulas for insomnia is to calm the mind， nourish the blood and soften the liver， eich the qi and activate blood. The effects of paste formula combinations are mainly strengthening spleen， nourishing heart and settling mind. The characteristics of new formula are diversified， and the law of clearing liver， reducing fire， communicating heart and kidney， eliminating conduction and medium-to-hidden therapy are explored， which can provide reference for clinical treatment of insomnia.

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